Symptoms & Treatment of Overdosage: The main symptoms of Diazepam overdosage are drowsiness, over-sedation and ataxia. When the effects of the drug overdosage begin to wear off, the patient exhibits some jitteriness and overstimulation. The cardinal manifestations of overdosage are drowsiness and confusion, reduced reflexes and coma. There are minimum effects on respiration, pulse and blood pressure unless the overdosage is extreme.
There is no specific antidote known. Gastric lavage may be beneficial if performed soon after oral ingestion of Diazepam. If necessary, a CNS stimulant such as caffeine or methylphenidate may be administered with caution. Supportive measures should be instituted as indicated: maintenance of an adequate airway, levarterenol or metaraminol bitartrate for hypotension. Dialysis appears to be of little value.